BDBM50586473 CHEMBL5079032

SMILES CCOc1cc2ncnc(NCCc3ccc(NC(=O)Nc4cc(Cl)ccc4OC)cc3)c2cc1F

InChI Key InChIKey=PBBRUKZHVDWECM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50586473   

TargetAurora kinase A(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50586473(CHEMBL5079032)
Affinity DataIC50: 352nMAssay Description:Inhibition of GST-tagged AURA Ser123 to 401 residues) (unknown origin) expressed in Sf9 insect cells using tetra-LLRASLG peptide as substrate incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50586473(CHEMBL5079032)
Affinity DataIC50: 23nMAssay Description:Inhibition of GST-tagged TRKA (G443 to G796 residues) (unknown origin) expressed in Sf9 insect cells using poly (Glu, Tyr) 4:1 as substrate incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetAurora kinase B(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50586473(CHEMBL5079032)
Affinity DataIC50: 512nMAssay Description:Inhibition of recombinant full length His-tagged human AURB expressed in baculovirus expression system using tetra-LLRASLG peptide as substrate incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed