BDBM50586377 CHEMBL5086254::US20240034730, Compound 7

SMILES Oc1nn2ccccc2c1C(=O)Nc1c(F)c(F)c(-c2cccs2)c(F)c1F

InChI Key InChIKey=NUNBTZCNWXVQIB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50586377   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery and Clinic

US Patent
LigandPNGBDBM50586377(CHEMBL5086254 | US20240034730, Compound 7)
Affinity DataIC50: 1.35nMAssay Description:The enzymatic inhibition assay was optimized for being performed on a 96 well plate and to achieve higher throughput. For each well of the plate a to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Drug Discovery and Clinic

US Patent
LigandPNGBDBM50586377(CHEMBL5086254 | US20240034730, Compound 7)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged DHODH expressed in Escherichia coli BL21(DE3) using dihydroorotate substrate preincubated for 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed