BDBM50586357 CHEMBL5080660

SMILES c1c(c(cc(c1OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O)OCCOc2cc(c(cc2OP(=O)(O)O)OP(=O)(O)O)OP(=O)(O)O

InChI Key InChIKey=SPZGMBGXCYAMCB-UHFFFAOYSA-N

Data  1 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50586357   

TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50586357(CHEMBL5080660)
Affinity DataIC50: 31nMAssay Description:Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarizati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50586357(CHEMBL5080660)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50586357(CHEMBL5080660)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2(Human)
University of East Anglia

Curated by ChEMBL
LigandPNGBDBM50586357(CHEMBL5080660)
Affinity DataKi:  4.90E+3nMAssay Description:Inhibition of human SHIP2 (419 to 732 residues) expressed in Escherichia coli by malachite green phosphate assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)