BDBM50586255 CHEMBL5077828

SMILES COc1cc2c(n[nH]c2cc1-c1ccnc(C)c1F)C(=O)N1CCN(C)CC1

InChI Key InChIKey=OLNAPNPRDCFCSN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50586255   

TargetToll-like receptor 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50586255(CHEMBL5077828)
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human TLR8 expressed in Drosophila S2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50586255(CHEMBL5077828)
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50586255(CHEMBL5077828)
Affinity DataIC50: 980nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed