BDBM50586249 CHEMBL5080083

SMILES COc1cc2cc[nH]c2cc1-c1ccncc1

InChI Key InChIKey=CCGSQZWVGGCGET-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50586249   

TargetToll-like receptor 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50586249(CHEMBL5080083)
Affinity DataIC50: 2nMAssay Description:Antagonist activity at human TLR8 expressed in Drosophila S2 by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50586249(CHEMBL5080083)
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at human TLR8 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated TNF level preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50586249(CHEMBL5080083)
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity at human TLR7 expressed in human PBMC cells assessed as inhibition of ssRNA stimulated IFNalpha level preincubated for 30 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetToll-like receptor 9(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50586249(CHEMBL5080083)
Affinity DataIC50: 3.60E+3nMAssay Description:Antagonist activity at human TLR9 expressed in human PBMC cells assessed as inhibition of ODN2216 stimulated IFNalpha level preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50586249(CHEMBL5080083)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human TLR4 expressed in human PBMC cells assessed as inhibition of LPS stimulated TNF level preincubated for 30 mins followed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed