BDBM50586222 CHEMBL5082786

SMILES Cc1c(cccn1)NC(=O)CSC2=Nc3c(c4c(s3)CN(CC4)C(=O)C)C(=O)N2Cc5ccco5

InChI Key InChIKey=PQYXGDZAWKQEEM-UHFFFAOYSA-N

Data  6 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50586222   

TargetBromodomain-containing protein 4(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of BRD4-BD1 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50: 130nMAssay Description:Inhibition of BRD4-BD2 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50: 20nMAssay Description:Inhibition of BRD3-BD2 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50: 71nMAssay Description:Inhibition of BRD2-BD2 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of BRD3-BD1 domain (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of BRD2-BD1 (unknown origin) incubated for 6 hrs by HTRF methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
Cnrs

Curated by ChEMBL
LigandPNGBDBM50586222(CHEMBL5082786)
Affinity DataKd:  150nMAssay Description:Inhibition of BRD3-BD2 (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed