BDBM50585771 CHEMBL5078192

SMILES CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3cc(ncc3F)N3CCOCC3)cc2n1

InChI Key InChIKey=KFRGPUFONMCXQI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50585771   

TargetCyclin-dependent kinase 5 activator 1(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585771(CHEMBL5078192)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585771(CHEMBL5078192)
Affinity DataIC50: 301nMAssay Description:Inhibition of full length N-terminal GST tagged human CDK2(1 to 298 residues)/CyclinA2 (1 to 432 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50585771(CHEMBL5078192)
Affinity DataIC50: 125nMAssay Description:Inhibition of full length N-terminal GST fused human CDK6 (1 to 326 residues)/CyclinD3 (1 to 292 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
LigandPNGBDBM50585771(CHEMBL5078192)
Affinity DataIC50: 78nMAssay Description:Inhibition of full length N-terminal GST fused human CDK7 (1 to 346 residues)/CyclinH (1 to 323 residues)/ MAT1 (1 to 309 residues) expressed in bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585771(CHEMBL5078192)
Affinity DataIC50: 154nMAssay Description:Inhibition of full length N-terminal GST fused human CDK9(1 to 372 residues)/ His- tagged CyclinT1 (1 to 726 residues) expressed in baculovirus expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585771(CHEMBL5078192)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Nano-Luc fused human full length CDK5/P35 transfected in HEK293 cells incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed