BDBM50585764 CHEMBL5088315

SMILES CN1CCC(CC1)[C@@](C)(O)c1ccc2cnc(Nc3ccc(cc3F)-c3cccn(C)c3=O)cc2n1

InChI Key InChIKey=RZDGEHGGZJUCEA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50585764   

TargetCyclin-dependent kinase 5 activator 1(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585764(CHEMBL5088315)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of full length N-terminal GST fused human CDK5(1 to 292 residues)/ p25 (99 to 307 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585764(CHEMBL5088315)
Affinity DataIC50: 264nMAssay Description:Inhibition of full length N-terminal GST tagged human CDK2(1 to 298 residues)/CyclinA2 (1 to 432 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Goldfinc Bio

Curated by ChEMBL
LigandPNGBDBM50585764(CHEMBL5088315)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Nano-Luc fused human full length CDK5/P35 transfected in HEK293 cells incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed