BDBM50585694 CHEMBL4878072::US12281080, SCCP 6148

SMILES CN1CCN(CC1)C(=O)c1ccc2cc(CCNc3ccnc4ccc(cc34)C#N)ccc2c1

InChI Key InChIKey=AFUHWZUYZJGVKM-UHFFFAOYSA-N

Data  2 IC50  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50585694   

TargetCyclin-C(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of kinase tracer 236 binding to His tagged recombinant human CDK8/cyclin C incubated for 60 min FRET based LanthaScreen Eu-Kinase binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase haspin(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to human HASPIN assessed as dissociation constant by KdELECT Discover assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  940nMAssay Description:Binding affinity to human MAP4K2 assessed as dissociation constant by KdELECT Discover assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetMyosin-IIIb(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human MYO3B assessed as dissociation constant by KdELECT Discover assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-C(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to kinase tracer 236 binding to His tagged recombinant human CDK8/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  2.90nMAssay Description:Binding affinity to recombinant human CDK19/cyclinC assessed as dissociation constant by TR FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  55nMAssay Description:Binding affinity to human CDK8 assessed as dissociation constant by KdELECT Discover assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 19(Human)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataKd:  44nMAssay Description:Binding affinity to human CDK19 assessed as dissociation constant by KdELECT Discover assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8/19(Human)
University of South Carolina

US Patent
LigandPNGBDBM50585694(CHEMBL4878072 | US12281080, SCCP 6148)
Affinity DataIC50: 3.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
Go to US Patent