BDBM50585442 CHEMBL5083542

SMILES Cc1ncc(cc1NC(=O)OC1CCOCC1)-c1ccc2nc(NC(=O)C3CC3)sc2c1

InChI Key InChIKey=CWGYJOVAHWYDTO-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50585442   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50585442(CHEMBL5083542)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERG expressed in CHO cells at -80 mV holding potential measured after 4mins by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50585442(CHEMBL5083542)
Affinity DataKd:  9.20nMAssay Description:Binding affinity to wild-type human partial length RIPK1 (M1 to K305 residues) expressed in bacterial expression system measured after 1 hr by Kinome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50585442(CHEMBL5083542)
Affinity DataIC50: 67nMAssay Description:Inhibition of RIPK1 (unknown origin) using MBP and ATP as substrate preincubated for 10 mins followed by substrate addition and measured after 120 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed