BDBM50585401 CHEMBL5083652

SMILES [H][C@]12CC[C@]([H])(CN(C1)c1nc(OCC34CCCN3CCC4)nc3c(F)c(ncc13)-c1cc(O)cc3cccc(C#C)c13)N2

InChI Key InChIKey=JFYPNKVDMZEUOJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50585401   

TargetGTPase KRas(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50585401(CHEMBL5083652)
Affinity DataIC50: 14nMAssay Description:Inhibition of KRAS G12D mutant in human AGS cells assessed as reduction in ERK phosphorylation measured after 3 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed