BDBM50585268 CHEMBL5088730

SMILES CCOc1cc2cn(Cc3nn(CC(O)=O)c(=O)c4ccccc34)nc2cc1Cl

InChI Key InChIKey=KYOMWVNVTYMNQQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50585268   

TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585268(CHEMBL5088730)
Affinity DataIC50: 149nMAssay Description:Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as inhibition of calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585268(CHEMBL5088730)
Affinity DataIC50: 113nMAssay Description:Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585268(CHEMBL5088730)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at human S1P2 in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585268(CHEMBL5088730)
Affinity DataIC50: 1.62E+3nMAssay Description:Antagonist activity at human S1P2 in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hrs in presence of 2% H...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed