BDBM50585252 CHEMBL5076177

SMILES COc1cc(OC)c(NC(=O)Cc2nn(CC(O)=O)c(=O)c3ccccc23)cc1Cl

InChI Key InChIKey=DUDPCONXMQGBNG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50585252   

TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585252(CHEMBL5076177)
Affinity DataIC50: 186nMAssay Description:Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as inhibition of calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585252(CHEMBL5076177)
Affinity DataIC50: 2.33E+4nMAssay Description:Agonist activity at human S1P2 receptor expressed in CHO cells assessed as increase in calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585252(CHEMBL5076177)
Affinity DataIC50: 1.99E+4nMAssay Description:Antagonist activity at human S1P1 receptor expressed in CHO cells assessed as inhibition of calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585252(CHEMBL5076177)
Affinity DataIC50: 464nMAssay Description:Antagonist activity at human S1P2 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Galapagos

Curated by ChEMBL
LigandPNGBDBM50585252(CHEMBL5076177)
Affinity DataIC50: 32nMAssay Description:Displacement of sphingosine D-erythro [3-3H] I- phosphate from human S1P2 receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed