BDBM50585204 CHEMBL5085698

SMILES C(Cc1cnc[nH]1)Nc1ccnc(Nc2cccc(CN3CCOCC3)c2)n1

InChI Key InChIKey=FTIGOWUZQQHANO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50585204   

TargetSerine/threonine-protein kinase 17A(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585204(CHEMBL5085698)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tracer K9 from NLuc fused DRAK1 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMAP/microtubule affinity-regulating kinase 3(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585204(CHEMBL5085698)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tracer K9 from NLuc fused MARK3 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMAP/microtubule affinity-regulating kinase 4(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585204(CHEMBL5085698)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tracer K5 from NLuc fused MARK4 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585204(CHEMBL5085698)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tracer K5 from NLuc fused TBK1 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585204(CHEMBL5085698)
Affinity DataIC50: 176nMAssay Description:Inhibition of recombinant human ARK5 (2 to end residues) using KKKVSRSGLYRSPSMPENLNRPR as substrate incubated for 40 mins in presence of [gamma-33ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase SIK2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585204(CHEMBL5085698)
Affinity DataIC50: 185nMAssay Description:Inhibition of recombinant human SIK2 (1 to 276 residues) using KKKVSRSGLYRSPSMPENLNRPR as substrate measured after 40 mins in presence of [gamma33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585204(CHEMBL5085698)
Affinity DataIC50: 537nMAssay Description:Inhibition of human ALK2 (147 to end residues) using casein as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBone morphogenetic protein receptor type-1B(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585204(CHEMBL5085698)
Affinity DataIC50: 9.03E+3nMAssay Description:Inhibition of recombinant human BMPR1B (148 to end residues) using casein as substrate incubated for 40 mins in presence of [gamma-33P-ATP] by radiom...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed