BDBM50585189 CHEMBL5083125

SMILES NS(=O)(=O)c1ccc(CNc2nc(Nc3cccc(CN4CCOCC4)c3)ncc2Br)cc1

InChI Key InChIKey=RDROKTFULACVDQ-UHFFFAOYSA-N

Data  19 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50585189   

TargetNUAK family SNF1-like kinase 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 171nMAssay Description:Inhibition of recombinant human ARK5 (2 to end residues) using KKKVSRSGLYRSPSMPENLNRPR as substrate incubated for 40 mins in presence of [gamma-33ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNUAK family SNF1-like kinase 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 7.01E+3nMAssay Description:Inhibition of NanoLuc-fused NUAK1 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBMP-2-inducible protein kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of NanoLuc-fused BMP2K (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PRP4 homolog(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PRP4 (663 to end residues) using casein as substrate incubated for 120 mins in presence of [gamma-33P-ATP] by radiome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-phosphate 5-kinase type-1 alpha(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human PIP5K1A using phosphatidylinositol 4-phosphate/phosphatidylserine as substrate incubated for 30 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of full length recombinant human CSNK2A1 using RRRDDDSDDD as substrate incubated for 40 mins in presence of [gamma-33P-ATP] by radiometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha'(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of full length recombinant human CSNK2A2 using RRRDDDSDDD a substrate incubated for 40 mins in presence of [gamma-33P-ATP] by radiometric ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ULK3(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of full length recombinant human ULK3 using casein as substrate incubated for 40 mins in presence of [gamma-33P-ATP] by radiometric scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 66nMAssay Description:Inhibition of human TTBK1 (1 to 479 residues) using Casein as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation counting...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 67nMAssay Description:Inhibition of human TYK2 (875 to end residues) using GGMEDIYFEFMGGKKK as substrate measured after 40 mins in presence of [gamma33P]ATP by radiometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 158nMAssay Description:Inhibition of human TrkA (440 to end residues) using KKKSPGEYVNIEFG as substrate measured after 40 mins in presence of [gamma33P]ATP by scintillation...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBMP-2-inducible protein kinase(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant human BIKe using peptide as substrate incubated for 120 mins in presence of [gamma-33ATP] by scintillation counting based r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAP2-associated protein kinase 1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 80nMAssay Description:Inhibition of human AAK1 using peptide as substrate incubated for 120 mins in presence of [gamma-33ATP] by scintillation counting based radiometry as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tracer K5 from NLuc fused TBK1 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMAP/microtubule affinity-regulating kinase 4(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tracer K5 from NLuc fused MARK4 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMAP/microtubule affinity-regulating kinase 3(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tracer K9 from NLuc fused MARK3 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17A(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of tracer K9 from NLuc fused DRAK1 (unknown origin) expressed in HEK293 cells by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 192nMAssay Description:Inhibition of recombinant human FMS (538 to end residues) using KKKSPGEYVNIEFG as substrate measured after 40 mins in presence of [gamma33P]ATP by ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 16(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50585189(CHEMBL5083125)
Affinity DataIC50: 88nMAssay Description:Inhibition of human STK16 in presence of [gamma-33P-ATP] by radiometric scintillation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed