BDBM50585081 CHEMBL5086749

SMILES Oc1cccc(c1)-c1nc2sccn2c1-c1ccnc(NCCCNS(=O)(=O)c2cccc(F)c2)n1

InChI Key InChIKey=IQNUESPLCMDNRV-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50585081   

TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human wild type BRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 5nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of ERN1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 4.88E+3nMAssay Description:Inhibition of HIPK1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 1.87E+3nMAssay Description:Inhibition of MAPK8 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 980nMAssay Description:Inhibition of MAPK11 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 1.78E+3nMAssay Description:Inhibition of MAPK14 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 20(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of ZAK (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM50585081(CHEMBL5086749)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of NTRK2 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed