BDBM50584941 CHEMBL5077167

SMILES Cc1nnc2n1nc(cc2NC3CCN(CC3)C)C(=O)N4[C@H]5Cc6ccccc6[C@@H]4CNC5=O

InChI Key InChIKey=JFALEKLXZVKEKY-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50584941   

TargetATPase family AAA domain-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Affinity DataIC50: 32nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATPase family AAA domain-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Affinity DataIC50: 300nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetATPase family AAA domain-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Affinity DataIC50: 3.16E+4nMAssay Description:Displacement of Alexafluor 647-JQ1 from GST-BRD4 BD1 BD2 (44 to 460 residues) (unknown origin) incubated for 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetATPase family AAA domain-containing protein 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Affinity DataIC50: 2.51E+3nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Affinity DataIC50: 3.16E+4nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-BRD4 BD1/BD2 (44 to 460 residues) (unknown origin) transfected in human HCT116 cells incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed