BDBM50584442 CHEMBL5092352

SMILES COc1ccc(-c2ncc([nH]2)C(=O)NCCCCCCC(=O)NO)c(OC)c1

InChI Key InChIKey=ZKSQKXYNAYAFIG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50584442   

TargetHistone deacetylase(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50584442(CHEMBL5092352)
Affinity DataIC50: 80nMAssay Description:Inhibition of HDAC in human HeLa nuclear extracts using fluorometric substrate incubated for 30 mins by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50584442(CHEMBL5092352)
Affinity DataIC50: 4.66E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in baculovirus expression system using Ac-Leu-Gly-Lys (Ac)-AMC as substrate preincubated for 5 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50584442(CHEMBL5092352)
Affinity DataIC50: 7.12E+3nMAssay Description:Inhibition of recombinant human His-tagged HDAC3 expressed in baculovirus insect cells using Ac-Leu-Gly-Lys (Ac)-AMC as substrate preincubated for 5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50584442(CHEMBL5092352)
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant human N-terminal GST tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys (Ac)-AMC as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Southern Medical University

Curated by ChEMBL
LigandPNGBDBM50584442(CHEMBL5092352)
Affinity DataIC50: 1.46E+4nMAssay Description:Inhibition of full length recombinant human C-terminal His tagged HDAC8 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-GlyLys (Tfa)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed