BDBM50583318 CHEMBL5075933

SMILES C[C@]1(Cn2c(cnc2C(N)=N1)C#N)c1cc(NC(=O)c2ccc(Cl)cn2)ccc1F

InChI Key InChIKey=YMBXEBSSLRFPOM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50583318   

TargetBeta-secretase 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50583318(CHEMBL5075933)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50583318(CHEMBL5075933)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of hERG expressed in HEK293 cells at -80 mV holding potential by automated patch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50583318(CHEMBL5075933)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human amyloid beta (1 to 42) in human SKNBE2 cells expressing wild-type amyloid precursor protein hAPP695 incubated for 18 hrs by sandw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50583318(CHEMBL5075933)
Affinity DataIC50: 900nMAssay Description:Inhibition of human CYP3A4 by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed