BDBM50583310 CHEMBL5082711

SMILES [H]/N=C(/NCC)\NC(=O)Nc1c(cccc1CC)CC

InChI Key InChIKey=VHGRQUGTHVVVTE-UHFFFAOYSA-N

Data  6 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50583310   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50583310(CHEMBL5082711)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERG expressed in HEK cells by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50583310(CHEMBL5082711)
Affinity DataIC50: 8.35E+3nMAssay Description:Inhibition of human Cav1.2 expressed in HEK cells by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50583310(CHEMBL5082711)
Affinity DataIC50: 3.75E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK cells by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50583310(CHEMBL5082711)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes pre-incubated for 30 min in presence of NADPH by LC-LS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50583310(CHEMBL5082711)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50583310(CHEMBL5082711)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed