BDBM50583269 CHEMBL5089609

SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)C\C=C/C[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc(O)cc1)C(O)=O

InChI Key InChIKey=CRQUBXFCBFENCK-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50583269   

TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583269(CHEMBL5089609)
Affinity DataEC50:  9.30nMAssay Description:Agonist activity at human APJ expressed in HEK293 cell membrane assessed as dissociation of G alphai1 from the G beta gamma subunit by BRET-based G p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583269(CHEMBL5089609)
Affinity DataEC50:  187nMAssay Description:Agonist activity at human APJ expressed in HEK293 cell membrane assessed as recruitment of PDZ-RhoGEF Galpha12 to cell membrane by BRET-based G prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583269(CHEMBL5089609)
Affinity DataEC50:  867nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as recruitment of beta-arrestin2 to receptor by BRET-based beta-arrestin2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583269(CHEMBL5089609)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]-[Nle75,Tyr77][Pyr1]-Ape13 from YFP-tagged human APJ expressed in HEK293 cell membranes assessed as inhibition constant incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed