BDBM50583267 CHEMBL5085866

SMILES CC(C)C[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)C\C=C/C[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@H](Cc1ccc2ccccc2c1)C(O)=O

InChI Key InChIKey=IIVCDBIBOGOXBU-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50583267   

TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583267(CHEMBL5085866)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human APJ expressed in HEK293 cell membrane assessed as dissociation of G alphai1 from the G beta gamma subunit by BRET-based G p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583267(CHEMBL5085866)
Affinity DataEC50:  2.40nMAssay Description:Agonist activity at human APJ expressed in HEK293 cell membrane assessed as recruitment of PDZ-RhoGEF Galpha12 to cell membrane by BRET-based G prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583267(CHEMBL5085866)
Affinity DataEC50:  232nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as recruitment of beta-arrestin2 to receptor by BRET-based beta-arrestin2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583267(CHEMBL5085866)
Affinity DataKi:  5.70nMAssay Description:Displacement of [125I]-[Nle75,Tyr77][Pyr1]-Ape13 from YFP-tagged human APJ expressed in HEK293 cell membranes assessed as inhibition constant incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed