BDBM50583264 CHEMBL5092604

SMILES CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCN(C\C=C\C[C@H](N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1)S(=O)(=O)c1ccccc1[N+]([O-])=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI Key InChIKey=KZSQPDJPAYDWML-UHFFFAOYSA-N

Data  1 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50583264   

TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583264(CHEMBL5092604)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human APJ expressed in HEK293 cell membrane assessed as dissociation of G alphai1 from the G beta gamma subunit by BRET-based G p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583264(CHEMBL5092604)
Affinity DataEC50:  441nMAssay Description:Agonist activity at human APJ expressed in HEK293 cell membrane assessed as recruitment of PDZ-RhoGEF Galpha12 to cell membrane by BRET-based G prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583264(CHEMBL5092604)
Affinity DataEC50:  403nMAssay Description:Agonist activity at human APJ expressed in HEK293 cells assessed as recruitment of beta-arrestin2 to receptor by BRET-based beta-arrestin2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetApelin receptor(Human)
University of Sherbrooke

Curated by ChEMBL
LigandPNGBDBM50583264(CHEMBL5092604)
Affinity DataKi:  8.60nMAssay Description:Displacement of [125I]-[Nle75,Tyr77][Pyr1]-Ape13 from YFP-tagged human APJ expressed in HEK293 cell membranes assessed as inhibition constant incubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed