BDBM50582976 CHEMBL5087151

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(F)(F)F)cc1-c1ccc2NC(=O)CC3(CCOCC3)Oc2c1

InChI Key InChIKey=OPUPLLZBHXWNJB-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50582976   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human recombinant cRAF measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant wild type BRAF measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant BRAF V600E mutant measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Eternity Bioscience

Curated by ChEMBL
LigandPNGBDBM50582976(CHEMBL5087151)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed