BDBM50582696 CHEMBL5076595

SMILES COC(=O)c1nc(N)nc(Nc2cc(F)c(I)c(F)c2)n1

InChI Key InChIKey=DATILFYUDSRBBK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50582696   

TargetCyclic GMP-AMP synthase(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50582696(CHEMBL5076595)
Affinity DataIC50: 240nMAssay Description:Inhibition of human cGAS assessed as reduction in 2,3-cGAMP synthesis by measuring ATP consumption incubated for 20 mins by Kinase Glo luminescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCyclic GMP-AMP synthase(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50582696(CHEMBL5076595)
Affinity DataIC50: 240nMAssay Description:Inhibition of human cGAS expressed in human THP-1 cells transfected with HT-DNA incubated for 20 mins in presence of ATP by luminescence based analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
Shanghai Institute of Materia Medica (Simm)

Curated by ChEMBL
LigandPNGBDBM50582696(CHEMBL5076595)
Affinity DataIC50: 240nMAssay Description:Inhibition of cGAS (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed