BDBM50582219 CHEMBL5072209::US11708359, Example 42::US11974987, Example 42

SMILES FC1(F)C2CN(CCC12c1ccccc1)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2

InChI Key InChIKey=CZNDCKHIMYPXHJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50582219   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50582219(CHEMBL5072209 | US11708359, Example 42 | US1197498...)
Affinity DataIC50: 203nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50582219(CHEMBL5072209 | US11708359, Example 42 | US1197498...)
Affinity DataIC50: 203nMAssay Description:Inhibition of human MGL expressed in human HeLa cells assessed as amount of cleaved glycerol measured after 1 hrs by flow through assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50582219(CHEMBL5072209 | US11708359, Example 42 | US1197498...)
Affinity DataIC50: 203nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent