BDBM50582215 CHEMBL5082727::US11708359, Example 5::US11974987, Example 5

SMILES CC(C)(C)c1ccc(cc1)C12CC1CN(C2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2

InChI Key InChIKey=FAXGUFGOHQOJOK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50582215   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50582215(CHEMBL5082727 | US11708359, Example 5 | US11974987...)
Affinity DataIC50: 1.40nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2024
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50582215(CHEMBL5082727 | US11708359, Example 5 | US11974987...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human MGL expressed in human HeLa cells assessed as amount of cleaved glycerol measured after 1 hrs by flow through assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50582215(CHEMBL5082727 | US11708359, Example 5 | US11974987...)
Affinity DataIC50: 1.40nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent