BDBM50582039 CHEMBL5080097

SMILES Cc1cc(C)cc(Nc2nccc(n2)-c2c(ncn2C2CCN(CCN)CC2)-c2ccc(cc2)C(F)(F)F)c1

InChI Key InChIKey=BRLZGRRJGHILMO-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50582039   

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50582039(CHEMBL5080097)
Affinity DataIC50: 940nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50582039(CHEMBL5080097)
Affinity DataIC50: 2.60E+4nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50582039(CHEMBL5080097)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50582039(CHEMBL5080097)
Affinity DataIC50: 130nMAssay Description:Inhibition of BRD4-BD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50582039(CHEMBL5080097)
Affinity DataIC50: 130nMAssay Description:Inhibition of 6-His tagged BRD4 BD1 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50582039(CHEMBL5080097)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) (333 to 460 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by fluorescence anisotro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed