BDBM50581727 CHEMBL5084744::US20240182406, Example 2

SMILES OC(=O)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)NC23CC4CC(Cl)(CC(C2)c2ccccc42)C3)cc1

InChI Key

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50581727   

TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM50581727(CHEMBL5084744 | US20240182406, Example 2)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant sEH using CMNPC as substrate incubated for 5 mins by fluorescent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM50581727(CHEMBL5084744 | US20240182406, Example 2)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of mouse recombinant sEH using CMNPC as substrate incubated for 5 mins by fluorescent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Rat)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM50581727(CHEMBL5084744 | US20240182406, Example 2)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat recombinant sEH using CMNPC as substrate incubated for 5 mins by fluorescent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM50581727(CHEMBL5084744 | US20240182406, Example 2)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant LOX-5 preincubated for 10 mins in presence of AA and ATP measured after 20 mins by fluorescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome c oxidase subunit 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM50581727(CHEMBL5084744 | US20240182406, Example 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM50581727(CHEMBL5084744 | US20240182406, Example 2)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of human recombinant CYP2C19 preincubated for 5 mins in presence of NADP+ by fluorescent assay relative to controlMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetEpoxide hydrolase 1(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50581727(CHEMBL5084744 | US20240182406, Example 2)
Affinity DataIC50: 0.400nMAssay Description:The fluorescent assay was used with purified recombinant human or mouse sEH proteins. The enzymes were incubated at 30° C. with the inhibitors ([I]fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
Go to US Patent