BDBM50581722 CHEMBL5081815::US20240182406, Example C1

SMILES CC(=O)N1CCC(CC1)NC(=O)NC12CC3CC(C)(CC(C1)c1ccccc31)C2

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50581722   

TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM50581722(CHEMBL5081815 | US20240182406, Example C1)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human recombinant sEH using CMNPC as substrate incubated for 5 mins by fluorescent based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBifunctional epoxide hydrolase 2(Human)
Unitat Associada Al Csic

Curated by ChEMBL
LigandPNGBDBM50581722(CHEMBL5081815 | US20240182406, Example C1)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human sEH using Nonfluorescent Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBifunctional epoxide hydrolase 2(Mouse)
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50581722(CHEMBL5081815 | US20240182406, Example C1)
Affinity DataIC50: 6nMAssay Description:Inhibition of mouse sEH in using using Nonfluorescent Cyano(6-methoxy-naphthalen-2-yl)methyl trans-[(3-phenyloxiran-2-yl)methyl] carbonate as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpoxide hydrolase 1(Human)
Universitat De Barcelona

US Patent
LigandPNGBDBM50581722(CHEMBL5081815 | US20240182406, Example C1)
Affinity DataIC50: 4nMAssay Description:The fluorescent assay was used with purified recombinant human or mouse sEH proteins. The enzymes were incubated at 30° C. with the inhibitors ([I]fi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2024
Entry Details
Go to US Patent