BDBM50581595 CHEMBL4215078

SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)COCCCOCCNC(=O)C[C@@H]1N=C(c2c(C)c(C)sc2-n2c(C)nnc12)c1ccc(Cl)cc1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

InChI Key InChIKey=PQOGZKGXGLHDGS-UHFFFAOYSA-N

Data  9 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50581595   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
University of California Santa Cruz

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  34nMAssay Description:Binding affinity to N-terminal His6-tagged VHL (54 to 213 residues) (unknown origin) expressed in Escherichia coli assessed as displacement of HIF-1a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  34nMAssay Description:Binding affinity to BRD2 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  4.70nMAssay Description:Binding affinity to BRD2 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  8.30nMAssay Description:Binding affinity to BRD3 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to BRD3 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  9.60nMAssay Description:Binding affinity to BRD4 BD1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to BRD4 BD2 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Xinxiang Medical University

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataEC50:  90nMAssay Description:Activation of caspase 3/7 in human 22Rv1 cells by Caspase-Glo reagent based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  9.60nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
"Sapienza" University of Rome

Curated by ChEMBL
LigandPNGBDBM50581595(CHEMBL4215078)
Affinity DataKd:  7.60nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed