BDBM50581213 CHEMBL5088687

SMILES Cc1nc(NCc2ncccc2F)c2c(c[nH]c2n1)-c1ccnc(N)c1

InChI Key InChIKey=MGEGGAFJSKMJJD-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50581213   

LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 30nMAssay Description:Inhibition of DYRK1A expressed in human U2OS cells assessed as reduction in autophosphorylation at S520 residue incubated for 5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 8nMAssay Description:Inhibition of DYRK1A (unknown origin) assessed as accumulation of ADP by ADP hunter plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 5nMAssay Description:Inhibition of DYRK1A (unknown origin) by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 7nMAssay Description:Inhibition of DYRK1B (unknown origin) by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 30nMAssay Description:Inhibition of DYRK2 (unknown origin) by ADP hunter plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK9 (unknown origin) by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 20nMAssay Description:Inhibition of DYRK2 (unknown origin) by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 20nMAssay Description:Inhibition of CLK (unknown origin) by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 30nMAssay Description:Inhibition of DYRK3 (unknown origin) by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581213(CHEMBL5088687)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of DYRK4 (unknown origin) by TR FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed