BDBM50581177 CHEMBL5075032

SMILES C[C@H](C(=O)N1CC2(C1)CC(C2)F)NC3=Nc4c(cnn4C5CCCC5)C(=O)N3

InChI Key InChIKey=GJXGHHNPNGRGBH-UHFFFAOYSA-N

Data  1 KI  16 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50581177   

LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 960nMAssay Description:Inhibition of PDE1C2 (147 to 531 residues) (unknown origin) using [3H]-cGMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE11A4 (588 to 911 residues) (unknown origin) using [3H]-cAMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE10A (449 to 770 residues) (unknown origin) using [3H]-cAMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) using [3H]-cAMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE7A1 (130 to 482 residues) (unknown origin) using [3H]-cAMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of PDE5A1 (535 to 860 residues) (unknown origin) using [3H]-cGMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4D2 (86 to 413 residues) (unknown origin) using [3H]-cAMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE3A (679 to 1087 residues) (unknown origin) using [3H]-cAMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE2A (580 to 919 residues) (unknown origin) using [3H]-cGMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of PDE9A2 (181 to 506 residues) (unknown origin) using [3H]-cGMP substrate measured for 15 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50581177(CHEMBL5075032)
Affinity DataKi:  7nMAssay Description:Binding affinity to PDE9A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed