BDBM50581133 CHEMBL5093835

SMILES [H][C@@]12CN(C[C@@]1(N=C(N)SC2)c1cccs1)c1ncc(F)cn1

InChI Key InChIKey=AEEUVUOXVOFFCH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50581133   

TargetBeta-secretase 1(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50581133(CHEMBL5093835)
Affinity DataIC50: 83nMAssay Description:Inhibition of recombinant human BACE1 using (MCA)-S-E-V-N-L-D-A-E-F-R-K(dinitrophenol)-R-R-R-R-NH2 as substrate incubated for 8 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetCathepsin D(Human)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50581133(CHEMBL5093835)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human Cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50581133(CHEMBL5093835)
Affinity DataIC50: 324nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed