BDBM50580879 CHEMBL5087242

SMILES COc1cc(NC(=O)c2ccccc2Nc2cccc(Cl)c2C)cc(OC)c1OC

InChI Key InChIKey=JQJLSDCXRGCLNB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50580879   

TargetProstaglandin G/H synthase 2(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50580879(CHEMBL5087242)
Affinity DataIC50: 1.17E+5nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated 10 mins followed by substrate addition and measured after 2 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50580879(CHEMBL5087242)
Affinity DataIC50: 5.09E+4nMAssay Description:Inhibition of human topoisomerase I using DNA pBR322 as substrate assessed as DNA relaxation incubated for 45 mins by ethidium bromide staining based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed