BDBM50580 (2Z)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-coumaran-3-one::(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one::(2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-3-benzofuranone::(2Z)-2-[[3,4-bis(oxidanyl)phenyl]methylidene]-6-oxidanyl-1-benzofuran-3-one::MLS000863576::SMR000440743::SULFURETIN::cid_5281295

SMILES Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(O)c(O)c1

InChI Key InChIKey=RGNXWPVNPFAADO-UHFFFAOYSA-N

Data  35 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50580   

TargetTyrosine-protein kinase BTK(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 6.02E+3nMAssay Description:Inhibition of human BTKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 9.32E+3nMAssay Description:Inhibition of human JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.44E+3nMAssay Description:Inhibition of human CDK6More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of recombinant GST-tagged DRAK2 (unknown origin) autophosphorylation after 2 hrs by ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human CDK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.16E+3nMAssay Description:Inhibition of human CDK9More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 950nMAssay Description:Inhibition of human TEKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 4.26E+3nMAssay Description:Inhibition of human JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.02E+3nMAssay Description:Inhibition of human ITKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetXanthine dehydrogenase/oxidase(Bovine)
National Academy of Sciences of Ukraine

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 3.10E+3nMAssay Description:Mixed-type inhibition of bovine milk xanthine oxidase assessed as enzyme-substrate-inhibitor complex using varying levels of xanthine as substrate by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2019
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 4.16E+3nMAssay Description:Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
Sunchon National University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human recombinant MAOB using benzylamine as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 3.62E+4nMAssay Description:Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 5.12E+4nMAssay Description:Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
TargetNeuraminidase(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
Universidad De Buenos Aires

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.96E+4nMAssay Description:Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
Target26S proteasome non-ATPase regulatory subunit 14(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.38E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 1.53E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Nikolovska-Coleska, Univer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase 33(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataEC50:  9.63E+3nMAssay Description:Keywords: STK33 Kinase, Non-ATP Competitive Inhibitor Assay Overview: Purified STK33 Kinase is preincubated with potential inhibitors and allowed to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2011
Entry Details
PCBioAssay
TargetIntestinal-type alkaline phosphatase(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 6.63E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetAlkaline phosphatase, germ cell type(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 6.72E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetAlkaline phosphatase, tissue-nonspecific isozyme(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 5.29E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
TargetIntestinal-type alkaline phosphatase 1(Rat)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 1.97E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2011
Entry Details
PCBioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataEC50:  424nMAssay Description:UNMCMD Assay Overview: Assay Support: 1 R03 MH087406-01A1 Project Title: Identification of broad-spectrum antifungal efflux pump inhibitors ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2012
Entry Details
PCBioAssay
TargetProthrombin(Bovine)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.17E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford Burnham Medical Research Institute (SBMRI, La Jolla, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2012
Entry Details
PCBioAssay
TargetCyclin-dependent kinase 5 activator 1(Human)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of CDK5/p25 (unknown origin) after 30 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAcetylcholinesterase(Mouse)
Kyung Hee University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 6.99E+5nMAssay Description:Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by modified Ellman'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 4.63E+3nMAssay Description:Inhibition of human SYKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetAurora kinase A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 850nMAssay Description:Inhibition of human AURORA-AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 17A(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 5.85E+3nMAssay Description:Inhibition of human DRAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetDeath-associated protein kinase 1(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of human DAPK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetDeath-associated protein kinase 2(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 3.07E+3nMAssay Description:Inhibition of human DAPK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetDeath-associated protein kinase 3(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.33E+3nMAssay Description:Inhibition of human DAPK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
East China Normal University

Curated by ChEMBL
LigandPNGBDBM50580(MLS000863576 | (2Z)-2-[(3,4-dihydroxyphenyl)methyl...)
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of human BLKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2019
Entry Details Article
PubMed