BDBM50579989 CHEMBL5080777

SMILES Cc1c(c(nn1C1CC2(C1)CN(C2)C(=O)C=C)-c1ccc(CC(C)(C)O)cc1)-c1c(Cl)c(C)cc2[nH]ncc12

InChI Key InChIKey=SEIQJBZDZNMNKY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579989   

TargetGTPase KRas(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50579989(CHEMBL5080777)
Affinity DataIC50: 12nMAssay Description:Inhibition of human KRAS G12C mutant incubated for 2 hrs by scintillation counter based covalent competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetGTPase KRas(Human)
Arrival Discovery

Curated by ChEMBL
LigandPNGBDBM50579989(CHEMBL5080777)
Affinity DataIC50: 12nMAssay Description:Inhibition of human KRAS G12C mutant incubated for 2 hrs by scintillation counter based covalent competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed