BDBM50579970 CHEMBL5077379::US11926614, Example 172

SMILES CCOc1ccc(nc1)-c1nnc(n1-c1ccncc1)C12CC(C1)(C2)NC(=O)c1ccnc2cccnc12

InChI Key InChIKey=FKNNNQBBGAPVML-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50579970   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Symeres

Curated by ChEMBL
LigandPNGBDBM50579970(CHEMBL5077379 | US11926614, Example 172)
Affinity DataIC50: 9.40nMAssay Description:Inhibition of recombinant human TNKS2 (873 to 1162 residues) incubated for 20 hrs in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Symeres

Curated by ChEMBL
LigandPNGBDBM50579970(CHEMBL5077379 | US11926614, Example 172)
Affinity DataIC50: 9.40nMAssay Description:Biochemical IC50 values for the following compounds were determined in accordance with the following protocol (see also Anumala et al., Discovery of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
Go to US Patent