BDBM50579858 CHEMBL5088102

SMILES COc1ccccc1Nc1nccc(n1)-c1cc2c([nH]1)C1(CCN(CC1)C(=O)C#CN(C)C)CNC2=O

InChI Key InChIKey=HXUNBLWPPKQBAN-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50579858   

TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579858(CHEMBL5088102)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of EGFR T790M/L858R double mutant (unknown origin) preincubated for 60 mins followed by substrate addition and further incubated for 60 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579858(CHEMBL5088102)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated for 60 mins followed by substrate addition and further incubated for 60 mins in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Acerta Pharma

Curated by ChEMBL
LigandPNGBDBM50579858(CHEMBL5088102)
Affinity DataEC50:  2.18E+3nMAssay Description:Inhibition of EGF-induced phosphorylation of EGFR T790M/L858R double mutant in human NCI-H1975 cells preincubated for 120 mins followed by EGF stimul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed