BDBM50579802 CHEMBL5081901

SMILES Cc1n[nH]c(C)c1CCCOc1cc(OCCCc2cn(CCOCCOCCOCCOCCNC(=O)C3CCC(CN4C(=O)C=CC4=O)CC3)nn2)cc(c1)C(O)=O

InChI Key InChIKey=AVALWFKKPLBJCO-UHFFFAOYSA-N

Data  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50579802   

TargetTransthyretin(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50579802(CHEMBL5081901)
Affinity DataKd:  516nMAssay Description:Binding affinity to human TTR assessed as binding constant in PBS buffer at pH 7.4 measured after 20 mins fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetInterleukin-2(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50579802(CHEMBL5081901)
Affinity DataKd:  851nMAssay Description:Induction of stability of human recombinant interleukin 2 assessed as binding affinity of drug-conjugated rIL2 to human TTR in PBS buffer at pH 7.4 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetInterleukin-2(Human)
University of The Pacific

Curated by ChEMBL
LigandPNGBDBM50579802(CHEMBL5081901)
Affinity DataEC50:  0.609nMAssay Description:Induction of stability of human recombinant interleukin 2 assessed as increase in mouse CTLL-2 cell proliferation measured after 48 hrs by WST-1 assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed