BDBM50578638 CHEMBL4873928

SMILES [H][C@@]12C[C@@H](C[C@]1([H])[C@@H]2CNC(=O)c1ccc(Cl)cc1)Oc1ccnc2ccc(F)cc12

InChI Key InChIKey=YNQNZOOVNCLJBO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50578638   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50578638(CHEMBL4873928)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Texas

Curated by ChEMBL
LigandPNGBDBM50578638(CHEMBL4873928)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins in presence of NADPH by LCMS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed