BDBM50578351 CHEMBL4862452

SMILES NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1NC12CC(C1)C2

InChI Key InChIKey=IRUBRQUHIORGIW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50578351   

TargetMitogen-activated protein kinase 8(Mouse)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578351(CHEMBL4862452)
Affinity DataIC50: 170nMAssay Description:Inhibition of JNK1 in mouse RAW264.7 cells assessed as inhibition of c-Jun phosphorylation incubated for 30 mins by cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578351(CHEMBL4862452)
Affinity DataIC50: 11nMAssay Description:Inhibition of JNK1 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50578351(CHEMBL4862452)
Affinity DataIC50: 13nMAssay Description:Inhibition of JNK2 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed