BDBM50578173 CHEMBL4871608::US12291516, Example 82

SMILES CC#CC(=O)N1CCCC[C@H]1c1nc(c(C(N)=O)n1N)-c1ccc(cc1)C(=O)Nc1cc(ccn1)C#N

InChI Key InChIKey=TWNLBBVCFXAXIV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50578173   

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578173(CHEMBL4871608 | US12291516, Example 82)
Affinity DataIC50: 46nMAssay Description:Inhibition of full-length N-terminal GST tagged BTK (2 to 659 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578173(CHEMBL4871608 | US12291516, Example 82)
Affinity DataIC50: 45.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent