BDBM50578170 CHEMBL4852748::US12291516, Example 98

SMILES CC#CC(=O)N1CCCC[C@H]1c1nc(c(C(N)=O)n1N)-c1ccc(cc1)C(=O)Nc1cc(Cl)ccn1

InChI Key InChIKey=XOAPJKUJUHGWJN-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50578170   

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 19nMAssay Description:Inhibition of full-length N-terminal GST tagged BTK (2 to 659 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 3.67E+3nMAssay Description:Inhibition of full-length N-terminal GST-tagged BMX (1 to 675 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of full-length N-terminal GST-tagged ITK (2 to 620 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal DYKDDDD-tagged EGFR (669 to 1210 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 19.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 19.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 1.08E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 19.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 1.65E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 19.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578170(CHEMBL4852748 | US12291516, Example 98)
Affinity DataIC50: 3.98E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent