BDBM50578148 CHEMBL4850186::US12291516, Example 84

SMILES Cc1ccnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C=C)n(N)c2C(N)=O)c1

InChI Key InChIKey=IBKWYNPFFOZRLP-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50578148   

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 18nMAssay Description:Inhibition of full-length N-terminal GST tagged BTK (2 to 659 residues) (unknown origin) expressed in Sf21 insect cells using NH2-ETVYSEVRK-biotin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 18.1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 3.46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 3.46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Henan Zhiwei Biomedicine

US Patent
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 114nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 3.46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase ITK/TSK(Human)
Henan Zhiwei Biomedicine

US Patent
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 608nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Henan Normal University

Curated by ChEMBL
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 3.46nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Henan Zhiwei Biomedicine

US Patent
LigandPNGBDBM50578148(CHEMBL4850186 | US12291516, Example 84)
Affinity DataIC50: 156nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2025
Entry Details
Go to US Patent