BDBM50577525 CHEMBL4848062

SMILES COc1nc(ccc1-n1cnc(C)c1)C1=NOC(C2CC2)C(N1)c1ccc(Cl)cc1

InChI Key InChIKey=IOQORVDNYPOZPL-UHFFFAOYSA-N

Data  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50577525   

TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataEC50:  9nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C8(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of gamma secretase (unknown origin) assessed as reduction in notch cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed