BDBM50577328 CHEMBL4875188

SMILES COc1ccccc1C1=C(Nc2cccc(c2)C#N)C(=O)NC1=O

InChI Key InChIKey=CRZIGHVWJFDSFR-UHFFFAOYSA-N

Data  2 KI  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50577328   

TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of NanoLuc-fused SLK (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused CDK7 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ICK(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused ICK (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of biotinylated full-length STK10 expressed in Escherichia coli DH10Bac assessed as transfer of radiolabelled phosphate from ATP by OMNIA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK4(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of NanoLuc-fused CLK4 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 25(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused YSK1 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase tousled-like 2(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NanoLuc-fused TLK2 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of NanoLuc-fused GSK3A (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase DCLK3(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused DCAMKL3 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of NanoLuc-fused JAK3 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 36nMAssay Description:Inhibition of GSK3beta (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 alpha(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 19nMAssay Description:Inhibition of GSK3alpha (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 70nMAssay Description:Inhibition of CLK2 (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 23nMAssay Description:Inhibition of STK10 (unknown origin) expressed in Sf9 cells assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of SLK (unknown origin) assessed as transfer of radiolabelled phosphate group from ATP by reaction biology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSTE20-like serine/threonine-protein kinase(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataKi:  3.70nMAssay Description:Binding affinity human SLK by binding displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University of Campinas (Unicamp)

Curated by ChEMBL
LigandPNGBDBM50577328(CHEMBL4875188)
Affinity DataKi:  26nMAssay Description:Binding affinity human STK10 by binding displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed