BDBM50577297 CHEMBL4851439

SMILES FC(F)c1cncc(c1)-c1ccc2ncc3nnc(C4=CCCOCC4)n3c2c1

InChI Key InChIKey=ATKHYZXUMVNCIO-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50577297   

LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 81nMAssay Description:Inhibition of DNA-PK (unknown origin) using biotin-PEG2-TWSLPLSQDSASE-amide as substrate incubated for 60 mins in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 394nMAssay Description:Displacement of 5-TAMRA-labelled Tracer A from human GST-fused/FLAG-tagged full length ATR/human N-terminal FLAG-tagged full length ATRIP expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 1.93E+4nMAssay Description:Inhibition of full-length N-terminal FLAG-tagged human ATM expressed in HEK293-6E cells using biotin-PEG2-SVEPPLSQETFSD as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 1.91E+3nMAssay Description:Inhibition of mTOR (unknown origin) using biotin-Ahx-PPGDYSTTPGGTLFSTTPGGTRI-amide as substrate incubated for 60 mins in presence of ATP by TR-FRET a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 117nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PI(4,5)P2 as substrate incubated for 60 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 69nMAssay Description:Inhibition of DNA-PK in human HT-144 cells assessed as reduction in gammaH2AX phosphorylation incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetAlpha-1-antitrypsin-related protein(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of ATR in human HT29 cells assessed as reduction in gammaH2AX phosphorylation incubated for 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human ERG expressed in HEK293 cells by automated voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 394nMAssay Description:Binding affinity to ATR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50577297(CHEMBL4851439)
Affinity DataIC50: 1.50E+4nMAssay Description:Competitive inhibition of CYP3A4 in human liver microsomes using midazolam as substrate by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed