BDBM50577277 CHEMBL4862738

SMILES Clc1cccc(c1)-c1ccc2ncc3nnc(C4CCOCC4)n3c2c1

InChI Key InChIKey=ZEXGCBYCYMHFPR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50577277   

LigandPNGBDBM50577277(CHEMBL4862738)
Affinity DataIC50: 330nMAssay Description:Inhibition of DNA-PK (unknown origin) using biotin-PEG2-TWSLPLSQDSASE-amide as substrate incubated for 60 mins in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50577277(CHEMBL4862738)
Affinity DataIC50: 1.22E+3nMAssay Description:Displacement of 5-TAMRA-labelled Tracer A from human GST-fused/FLAG-tagged full length ATR/human N-terminal FLAG-tagged full length ATRIP expressed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50577277(CHEMBL4862738)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of full-length N-terminal FLAG-tagged human ATM expressed in HEK293-6E cells using biotin-PEG2-SVEPPLSQETFSD as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
LigandPNGBDBM50577277(CHEMBL4862738)
Affinity DataIC50: 6.45E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PI(4,5)P2 as substrate incubated for 60 mins in presence of ATP by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed