BDBM50577063 CHEMBL4868987

SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-c2ccccc-12)-[#6](-[#6]-[#6]-[#8])-[#6](=O)-[#7]-[#6]-c1ccccc1

InChI Key InChIKey=UZVQKSJYFADGOZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50577063   

TargetSodium- and chloride-dependent GABA transporter 1(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577063(CHEMBL4868987)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of mouse GAT1 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium- and chloride-dependent betaine transporter(Mouse)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577063(CHEMBL4868987)
Affinity DataIC50: 1.78E+4nMAssay Description:Inhibition of mouse GAT2 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577063(CHEMBL4868987)
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of mouse GAT3 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mouse)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577063(CHEMBL4868987)
Affinity DataIC50: 2.51E+4nMAssay Description:Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577063(CHEMBL4868987)
Affinity DataIC50: 978nMAssay Description:Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50577063(CHEMBL4868987)
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibition of human recombinant BACE1 using Rh-EVNLDAEFK-quencher as substrate incubated for 60 mins by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed